Recent Publications
Pijning AE, Butera D, Hogg PJ (2026) Multiple disulfide‐bonded states confer extensive conformational diversity in fibrinogen. Protein Science 35, e70558. DOI: 10.1002/pro.70558
Butera D, Pijning AE, Avery NG, Coxon CH, Metcalfe C, Mimoun A, Lacroix-Desmazes S, Spiegel PC, Hogg PJ (2025) Patient anti-FVIII drug antibodies bind preferentially to a subset of FVIII covalent states. Blood Advances 9, 3706–3715. DOI: 10.1182/bloodadvances.2025016474
Ang CG, Hyatt NL, Minh GL, Gupta M, Kadam M, Hogg PJ, Smith AB, Chaiken IM (2025) Conformational activation and disulfide exchange in HIV-1 Env induce cell-free lytic/fusogenic transformation and enhance infection. Journal of Virology 99, e01471. DOI: 10.1128/jvi.01471-24
Lv K, Chen S, Xu X, Chiu J, Wang HJ, Han Y, Yang X, Bowley SR, Wang H, Tang Z, Tang N, Yang A, Yang S, Wang J, Jin S, Wu Y, Schmaier AH, Ju LA, Hogg PJ, Fang C (2024) Protein disulfide isomerase cleaves allosteric disulfides in histidine-rich glycoprotein to regulate thrombosis. Nature Communications 15, 3129. DOI: 10.1038/s41467-024-47493-0
Dupuy A, Aponte-Santamaría C, Yeheskel A, Graeter F, Hogg PJ*, Passam F, Chiu J (2023) Mechano-redox control of Mac-1 de-adhesion from ICAM-1 by protein disulfide isomerase promotes directional movement under flow. Circulation Research 132, e151-e168. DOI: 10.1161/CIRCRESAHA.122.321926, Selected for the cover.
Lay AJ, Dupuy A, Hagimola L, Tieng J, Larance M, Zhang Y, Yang J, Kong YX, Chiu J, Gray EC, Qin Z, Schmidt D, Maclean JAA, Hofma BR, Ellis ML, Kalev-Zylinska ML, Argon Y, Jackson SP, Hogg PJ*, Passam FH (2023) Endoplasmic reticulum protein 5 attenuates platelet endoplasmic reticulum stress and secretion in a mouse model. Blood Advances 7, 1650-1665. DOI: 10.1182/bloodadvances.2022008457. Selected for the cover.
Butera D, Wang HJ, Woon HG, Zhao YC, Ju LA, Hogg PJ (2022) Mechano-covalent protection of coagulation factor VIII by von Willebrand factor. Blood Advances 7, 2117-2128. DOI: 10.1182/bloodadvances.2022008650. Selected for the cover.
Ho Shon I, Hennessy T, Guille J, Gotsbacher MP, Lay AJ, McBride B, Codd R, Hogg PJ (2022) A first-in-human study of [68Ga]Ga-CDI: a positron emitting radiopharmaceutical for imaging tumour cell death. European Journal of Nuclear Medicine and Molecular Imaging. 49, 4037-4047. DOI: 10.1007/s00259-022-05880-z
Pijning AE, Blyth MT, Coote ML, Passam F, Chiu J, Hogg PJ (2021) An alternate covalent form of platelet αIIbβ3 integrin that resides in focal adhesions and has altered function. Blood 138, 1359-1372. DOI: 10.1182/blood.2021012441. Selected for the cover.
Flórido M, Chiu J, Hogg PJ (2021) Influenza A virus hemagglutinin is produced in different disulfide-bonded states. Antioxidants & Redox Signaling. 35, 1081-1092. DOI: 10.1089/ars.2021.0033. Selected for the cover.
Butera D and Hogg PJ (2020) Fibrinogen function achieved through multiple covalent states. Nature Communications 11, 5468 DOI: 10.1038/s41467-020-19295-7
Chiu J, Hogg PJ. (2019) Allosteric disulfides: Sophisticated molecular structures enabling flexible protein regulation. Journal of Biological Chemistry 294(8), 2949-2960. DOI: 10.1074/jbc.REV118.005604