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Current Research Projects
An intrinsic property of coagulation proteins that underlies autoantibody recognition
Hypothesis: The disulfide bond status of self-antigens governs autoantibody recognition.
A new indicator of platelet reactivity in bleeding and clotting
Hypothesis: The state of the platelet β3 integrin C177-C184 disulfide bond is a barometer of platelet reactivity.
Allosteric disulfide control of CD8+ T cells
Hypothesis: The CD8α C43-C115 disulfide is an allosteric bond that regulates the co-receptor function of CD8.
An intrinsic property of antibodies that facilitates antigen recognition
Hypothesis: The disulfide bond states of antibodies influences antigen recognition.
Use of CDI-PET to identify patients with solid malignancy not responding to immune checkpoint inhibitor treatment
Hypothesis: The Hogg lab has developed a molecule that detects dying and dead tumour cells with very high specificity and sensitivity, called Cell Death Indicator or CDI. CDI has been labelled for positron emission tomography imaging and will be used to identify cancer patients not responding to immune checkpoint inhibitor treatment.
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